I use Carbonite and like it. It is just a simple unlimited backup for $50.00 a year. It does not have any advanced features such as multiple versions. The uploads are caped at 2GB a day so it will take a couple of weeks to get all of your data backed up. Restores can be done at 15GB a day.
I used Amazon S3 with http://www.maluke.com/s3man/ for a while, but changed over to Mozy a month or so ago. I back-up all my music, videos (including all .tivo files) and pictures. The size of my back-up set would cost be double with S3.
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