Ok, I just installed the brand new DirecTv with Tivo HD box, model THR-22. The Harmony 720 doesn't find compatible software to setup the Harmony remote. I input the original remote key presses it asks for and I get partial access to this new box. The main Tivo functions don't, function that is. Any suggestions? My wife is not happy, the Harmony is hers. So far we are really happy with the thr22, I really like dual buffers and 30 second skip having multiple skips added up. As in 3 presses of that button = 90 seconds. Sweet!