I've been out of the loop for a while and am thinking about coming back to Plex. Right now I have a Windows Media Center PC w/XBox 360 as an extender. I also have Plex running on that WMC machine and use a nettop PC in the other room (running XBMC w/PleXBMC) for playing back high-bitrate Blu-ray rips, etc., that are stored on the main server.
I think the answer is "no" based on the searching I've done here, but I'm wondering if it's possible to have an all-in-one solution with a Roamio playing back my high-bitrate movies. What, if any, options are there and what are the pros/cons involved?