While I'm enjoying the compact form factor and response of the new Roamio remote, I must admit I've managed to pick it up wrong-end forward about 50% of the time!
The thing is nearly perfectly symmetrical - in shape, weight, balance and texture. Argh!
My old Glow Remote at least had a ribbed texture on the bottom and a flat/dimple near the top. When I grab that remote, I can clearly orient the thing by touch with no difficulty. Also, the IR window on the front tip of the Glow has a distinctive "edge" to it that also helps orient by touch.
There is a ribbed texture on the new Roamio remote, but it's right in the center and the flats/dimples are symmetrically positioned at each end. There is no visible IR window.
My only non-visual index is the small fingernail gap in the battery door at the bottom of the remote. Falls right at the tip of my pinky finger as I hold the thing. Maybe I'll get better at it with time.